Icosanoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, ALOX5, and ALYREF, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid biosynthetic process activity versus AIF1 in GBM (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AIF1 →	+0.881	+0.120	<.001	<.001	3	8
GBM	ALOX5 →	+0.882	+0.116	<.001	<.001	3	8
GBM	ALYREF →	-0.332	-0.077	<.001	<.001	3	8
GBM	APOBR →	+0.510	+0.100	<.001	<.001	3	8
GBM	ARHGDIB →	+0.800	+0.120	<.001	<.001	3	8
GBM	PLEKHO2 →	+0.392	+0.110	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046456 vs AIF1 — GBM

Explore this scatter interactively →