Icosanoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, TNFSF14, and BTK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid biosynthetic process activity versus PLA2G4A in LSCC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLA2G4A →	+1.181	+0.212	<.001	<.001	3	6
GBM	TNFSF14 →	+0.759	+0.198	.001	<.001	3	6
COAD	BTK →	+0.749	+0.180	<.001	.001	3	5
GBM	VNN2 →	+0.879	+0.227	<.001	<.001	3	5
BRCA	SLAMF1 →	+0.671	+0.218	.008	<.001	3	5
COAD	CD53 →	+0.893	+0.207	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046456 vs PLA2G4A — LSCC

Explore this scatter interactively →