Icosanoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEF, IL1B, and GCSHP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEF grouped by Icosanoid biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TEF →	-0.398	-1.463	<.001	<.001	3	6
CNS	IL1B →	-0.156	-0.797	.002	.001	3	6
OVARY	GCSHP3 →	-0.194	-1.333	.001	<.001	3	6
OVARY	MLC1 →	-0.483	-1.264	<.001	<.001	3	5
PANCREAS	ACCS →	-0.239	-0.995	.006	.006	3	5
OVARY	RRAD →	-0.170	-0.876	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEF by Icosanoid biosynthetic process activity — OVARY

Explore this box plot interactively →