Icosanoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Icosanoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HS6ST1, TOB1, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HS6ST1 grouped by Icosanoid biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HS6ST1 →	-2.260	-1.816	.004	<.001	3	5
URINARY_TRACT	TOB1 →	-2.056	-2.030	<.001	<.001	3	5
LUNG_SCLC	IKBIP →	+2.392	+1.245	<.001	<.001	3	4
OVARY	LURAP1L →	-1.941	-1.125	<.001	.002	2	5
UPPER_AERODIGESTIVE_TRACT	NOP16 →	+1.279	+1.110	.006	.002	2	5
BLOOD_Myeloma	FBXL6 →	-1.438	-1.356	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HS6ST1 by Icosanoid biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →