Ribose phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ribose phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, UCHL1, and GPRIN1_S704, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribose phosphate biosynthetic process activity versus SEPTIN4_S432 in GBM (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.994	+0.051	<.001	<.001	3	5
UCEC	UCHL1 →	+0.763	+0.048	.007	.006	3	4
OV	GPRIN1_S704 →	+0.964	+0.023	.009	.005	3	4
GBM	TINAGL1 →	+0.372	+0.037	.004	.001	3	4
GBM	TXNDC5 →	-0.561	-0.045	<.001	<.001	3	4
HNSC	WNK2_S1862 →	+0.899	+0.045	<.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046390 vs SEPTIN4_S432 — GBM

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