Ribose phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ribose phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIN2, PAQR5, and PLEKHN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribose phosphate biosynthetic process activity versus RIN2 in LSCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIN2 →	-0.978	-0.280	.001	.005	3	3
PDAC	PAQR5 →	-0.536	-0.124	.004	.005	3	3
HNSC	PLEKHN1 →	-0.813	-0.164	.003	.004	3	3
HNSC	UNC5B →	-0.785	-0.163	<.001	.001	3	3
COAD	IGKV1-37 →	+0.134	+0.125	.005	.001	3	3
OV	SHD →	+0.206	+0.213	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046390 vs RIN2 — LSCC

Explore this scatter interactively →