Ribose phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribose phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLFML2A, NRBF2, and SLC9A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OLFML2A grouped by Ribose phosphate biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OLFML2A →	-1.090	-0.209	.002	.002	3	5
BLOOD_Leukemia	NRBF2 →	-0.437	-0.183	.008	.007	3	4
LUNG_NSCLC_LUSC	SLC9A9 →	-1.791	-0.363	.002	<.001	3	4
SKIN	STPG2 →	-0.032	-0.219	<.001	<.001	3	4
STOMACH	ATP2C2 →	+2.567	+0.255	<.001	.001	3	4
STOMACH	BRI3BP →	+1.796	+0.252	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OLFML2A by Ribose phosphate biosynthetic process activity — BREAST

Explore this box plot interactively →