Ribose phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ribose phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETNK2, SEPTIN4, and RUVBL1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribose phosphate biosynthetic process activity versus ETNK2 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ETNK2 →	+1.644	+0.074	.001	.002	3	15
OESOPHAGUS	SEPTIN4 →	+1.879	+0.094	<.001	<.001	3	13
PANCREAS	RUVBL1 →	+1.030	+0.069	.002	.003	3	13
OESOPHAGUS	ARHGEF25 →	+2.394	+0.096	<.001	<.001	3	13
BLOOD_Lymphoma	CASTOR2 →	+0.807	+0.055	<.001	.001	3	13
BONE	DUSP9 →	+1.696	+0.098	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046390 vs ETNK2 — OESOPHAGUS

Explore this scatter interactively →