Monosaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Monosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF2BPL, TRADD, and TP53INP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF2BPL grouped by Monosaccharide catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IRF2BPL →	-1.156	-0.343	.003	.002	3	5
BLOOD_Lymphoma	TRADD →	-1.539	-0.373	<.001	.005	3	5
BREAST	TP53INP2 →	-1.182	-0.437	.008	.008	3	5
OESOPHAGUS	SRD5A3 →	-0.948	-0.246	.001	.006	3	5
BLOOD_Lymphoma	CLCN7 →	-1.486	-0.351	.001	.002	3	5
BLOOD_Lymphoma	ADCK1 →	-1.390	-0.342	.008	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF2BPL by Monosaccharide catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →