Monosaccharide catabolic process

Across TCGA cell cohorts, RNA activity of the Monosaccharide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENO2, IFT81, and CGN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide catabolic process activity versus ENO2 in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ENO2 →	+2.427	+0.334	<.001	<.001	3	7
LARGE_INTESTINE	IFT81 →	+0.800	+0.236	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CGN →	-1.849	-0.251	<.001	<.001	3	5
URINARY_TRACT	POLK →	+1.002	+0.623	.002	.003	3	5
LUNG_SCLC	PLCB4 →	+1.801	+0.211	<.001	<.001	3	4
LUNG_SCLC	ATP6V0E2 →	+0.868	+0.260	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046365 vs ENO2 — LUNG_SCLC

Explore this scatter interactively →