Monosaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Monosaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HADH, MRPL9, and UGDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide biosynthetic process activity versus HADH in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HADH →	+0.812	+0.262	.004	.005	3	5
UPPER_AERODIGESTIVE_TRACT	MRPL9 →	+0.524	+0.308	<.001	<.001	3	5
LUNG_NSCLC_LUSC	UGDH →	+3.112	+0.442	.002	.003	2	6
STOMACH	TXN2 →	+0.917	+0.312	.005	.002	3	5
STOMACH	ETFDH →	+0.719	+0.245	.004	.003	3	5
SKIN	MRPS34 →	+0.766	+0.338	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046364 vs HADH — UPPER_AERODIGESTIVE_TRACT

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