Amino sugar catabolic process

Across TCGA cell cohorts, RNA activity of the Amino sugar catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP16, PAXBP1, and UBE2G2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP16 grouped by Amino sugar catabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP16 →	-0.728	-1.697	<.001	<.001	3	3
OESOPHAGUS	PAXBP1 →	-0.783	-0.373	.002	.005	3	3
OESOPHAGUS	UBE2G2 →	-0.778	-0.354	.003	.002	3	3
OESOPHAGUS	QSER1 →	-0.657	-0.315	.001	.003	3	3
BLOOD_Myeloma	CHST14 →	-1.295	-1.868	.006	<.001	3	3
OVARY	ZNF268 →	+0.642	+1.224	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP16 by Amino sugar catabolic process activity — SKIN

Explore this box plot interactively →