Phosphatidylethanolamine metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylethanolamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNB5, CYB5R2, and SIAH2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine metabolic process activity versus GNB5 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNB5 →	+0.424	+0.141	.003	.009	3	4
CCRCC	CYB5R2 →	+0.340	+0.224	.001	.002	2	4
CCRCC	SIAH2-AS1 →	+0.374	+0.298	.001	<.001	3	3
UCEC	RPL21P32 →	+0.412	+0.177	.004	.001	3	3
PDAC	LINC01712 →	+0.307	+0.180	.005	.003	3	3
LSCC	OSGIN1 →	+1.211	+0.185	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046337 vs GNB5 — UCEC

Explore this scatter interactively →