Phosphatidylethanolamine metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylethanolamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HECTD2, LIX1L, and KIF3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine metabolic process activity versus HECTD2 in STOMACH (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HECTD2 →	-1.399	-0.937	.003	.002	3	5
BLOOD_Leukemia	LIX1L →	-0.703	-0.630	.009	.004	2	6
OESOPHAGUS	KIF3A →	-0.923	-0.953	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	USP15 →	-0.708	-1.146	.004	<.001	3	5
BLOOD_Myeloma	UBTF →	-0.661	-0.470	<.001	<.001	3	5
STOMACH	OGFRL1 →	-1.995	-0.978	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046337 vs HECTD2 — STOMACH

Explore this scatter interactively →