Positive regulation of JNK cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of JNK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFATC2, SASH3_S97, and LCP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of JNK cascade activity versus NFATC2 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFATC2 →	+0.348	+0.037	<.001	<.001	3	9
LSCC	SASH3_S97 →	+0.655	+0.039	<.001	<.001	3	8
GBM	LCP1 →	+0.998	+0.055	<.001	<.001	3	8
GBM	RRP9 →	-0.471	-0.054	<.001	<.001	3	8
LSCC	SH3D19 →	+0.340	+0.064	<.001	<.001	3	8
GBM	TBC1D2B →	+0.352	+0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046330 vs NFATC2 — GBM

Explore this scatter interactively →