Positive regulation of JNK cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNIK, BEST1, and P2RY13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of JNK cascade activity versus TNIK in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNIK →	+0.967	+0.939	<.001	<.001	3	5
LUAD	BEST1 →	+0.301	+0.651	.005	.001	3	5
UCEC	P2RY13 →	+0.908	+0.799	<.001	<.001	3	5
OV	HTR5A-AS1 →	+0.019	+0.906	.003	<.001	3	4
GBM	FCHO1 →	+0.825	+1.028	<.001	<.001	3	4
HNSC	URB1-AS1 →	-0.717	-0.643	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046330 vs TNIK — LSCC

Explore this scatter interactively →