Positive regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALR, IBTK, and DNM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALR grouped by Positive regulation of JNK cascade-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CALR →	-0.859	-0.915	.004	.008	2	4
CNS	IBTK →	-0.661	-1.061	<.001	.001	3	3
SKIN	DNM2 →	-0.449	-1.137	<.001	<.001	3	3
SOFT_TISSUE	RPL35 →	+0.887	+0.808	.002	.002	3	3
CNS	MATN2 →	-1.946	-0.843	.006	.004	3	3
CNS	PGM3 →	-0.817	-1.029	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALR by Positive regulation of JNK cascade activity — SKIN

Explore this box plot interactively →