Positive regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL7, ZMYND8, and ZNF114, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of JNK cascade activity versus RPL7 in OESOPHAGUS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPL7 →	+0.692	+1.081	.005	<.001	3	4
OVARY	ZMYND8 →	+0.803	+0.756	.001	.004	3	4
KIDNEY	ZNF114 →	-1.695	-1.260	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	SHLD1 →	+0.873	+1.219	<.001	<.001	3	4
URINARY_TRACT	SEC24D →	+1.057	+1.519	.002	.003	3	3
URINARY_TRACT	CAVIN3 →	+3.237	+1.433	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046330 vs RPL7 — OESOPHAGUS

Explore this scatter interactively →