Negative regulation of JNK cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, CORO1C, and NACAD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of JNK cascade activity versus SERPINE1 in BRCA (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINE1 →	-0.832	-0.687	<.001	<.001	3	4
BRCA	CORO1C →	-0.385	-0.568	<.001	<.001	3	4
BRCA	NACAD →	-0.306	-0.546	.004	.001	3	4
BRCA	THY1 →	-1.097	-1.116	<.001	<.001	3	4
BRCA	RAET1L →	-0.593	-0.926	.002	<.001	3	4
COAD	PHLDB2 →	-0.742	-0.835	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046329 vs SERPINE1 — BRCA

Explore this scatter interactively →