Negative regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, SOD1, and LAMA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of JNK cascade activity versus GSTP1 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GSTP1 →	+3.874	+1.000	.002	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	SOD1 →	+0.801	+0.944	.002	.005	3	5
LARGE_INTESTINE	LAMA3 →	-1.774	-0.765	.002	.009	3	5
PANCREAS	MLST8 →	+0.584	+0.797	.004	.004	3	5
OVARY	DAAM1 →	-1.360	-0.744	.005	.008	3	4
OVARY	MYG1 →	+0.491	+0.624	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046329 vs GSTP1 — BREAST

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