Regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, FLNB, and TGFB1I1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYL9 grouped by Regulation of JNK cascade-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MYL9 →	-5.516	-0.176	<.001	<.001	3	3
CNS	FLNB →	-1.261	-0.615	<.001	<.001	3	3
CNS	TGFB1I1 →	-1.734	-0.837	.005	.002	3	3
CNS	TENM2 →	-2.813	-0.780	<.001	.001	3	3
CNS	TPM4 →	-1.291	-0.695	<.001	.003	3	3
CNS	MTMR2 →	-0.554	-0.575	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYL9 by Regulation of JNK cascade activity — LIVER

Explore this box plot interactively →