Glucose import

pathway activity — cross-omics
GO:0046323Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glucose import pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, PLN, and NXPH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMSRB3 →+1.540+0.824<.001<.00138
UCECPLN →+1.169+0.584<.001<.00137
UCECNXPH3 →+0.665+0.727.001<.00137
GBMSPARCL1 →+0.802+0.182<.001<.00137
UCECLMOD1 →+1.709+0.707<.001<.00128
UCECLHFPL6 →+0.791+0.554.001.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration