Negative regulation of fatty acid oxidation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP1B, TNS2_S102, and FERMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid oxidation activity versus RRP1B in OV (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RRP1B →	-0.321	-0.032	<.001	.001	3	5
LUAD	TNS2_S102 →	+0.520	+0.044	<.001	<.001	3	5
BRCA	FERMT2 →	+0.540	+0.026	.001	.001	3	5
GBM	NES →	+0.488	+0.086	.002	<.001	3	5
BRCA	BDH2 →	+0.495	+0.027	<.001	<.001	3	5
LUAD	WDR36 →	-0.199	-0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046322 vs RRP1B — OV

Explore this scatter interactively →