Negative regulation of fatty acid oxidation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L1, SEMA3G, and ADCY6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid oxidation activity versus ALDH1L1 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALDH1L1 →	+1.020	+0.732	.003	.005	3	5
BRCA	SEMA3G →	+0.966	+0.382	<.001	<.001	3	5
BRCA	ADCY6 →	+0.753	+0.391	<.001	.006	3	5
CCRCC	TMEM252 →	+1.247	+0.459	.005	.005	3	4
GBM	ALDH6A1 →	+0.377	+0.570	.001	<.001	3	4
HNSC	SELPLG →	+0.748	+0.355	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046322 vs ALDH1L1 — UCEC

Explore this scatter interactively →