Negative regulation of fatty acid oxidation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIDINS220, TIAM2, and SENP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIDINS220 grouped by Negative regulation of fatty acid oxidation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIDINS220 →	-0.962	-1.191	.001	<.001	3	5
LUNG_SCLC	TIAM2 →	-1.455	-1.044	<.001	.002	3	4
LUNG_SCLC	SENP2 →	-0.894	-1.756	<.001	<.001	3	4
URINARY_TRACT	DRC3 →	-1.039	-1.550	<.001	<.001	3	4
LUNG_SCLC	BCL3 →	+2.357	+1.390	.002	<.001	3	4
LIVER	TMPRSS2 →	+1.735	+1.458	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIDINS220 by Negative regulation of fatty acid oxidation activity — LUNG_SCLC

Explore this box plot interactively →