Negative regulation of fatty acid oxidation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid oxidation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF4L2, ELF5, and RTP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCAF4L2 grouped by Negative regulation of fatty acid oxidation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCAF4L2 →	+0.221	+0.312	.002	<.001	3	3
STOMACH	ELF5 →	+0.172	+0.346	.007	.004	2	4
LARGE_INTESTINE	RTP1 →	+0.136	+0.394	.006	<.001	3	3
PANCREAS	SLC39A4 →	+0.208	+0.291	.001	.004	3	3
CNS	IGFBP3 →	-0.254	-0.237	.007	.002	3	3
BREAST	ZMYM5 →	-0.233	-0.446	.003	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCAF4L2 by Negative regulation of fatty acid oxidation activity — SKIN

Explore this box plot interactively →