Positive regulation of fatty acid oxidation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fatty acid oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAP2, AKAP12_T1760, and IRS2_S1100, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid oxidation activity versus STAP2 in LSCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAP2 →	-0.493	-0.038	<.001	<.001	3	5
BRCA	AKAP12_T1760 →	+0.570	+0.040	.002	<.001	3	5
LUAD	IRS2_S1100 →	+1.111	+0.037	<.001	<.001	3	5
HNSC	ZBTB20_S353 →	+0.362	+0.049	<.001	<.001	3	5
COAD	AUH →	+0.375	+0.025	.001	.005	3	4
COAD	THRAP3_S377 →	+0.530	+0.040	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046321 vs STAP2 — LSCC

Explore this scatter interactively →