Positive regulation of fatty acid oxidation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, USP34, and ATP6V1B2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid oxidation activity versus CPT1A in LUNG_SCLC (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CPT1A →	+2.131	+1.613	<.001	<.001	3	7
OESOPHAGUS	USP34 →	-0.985	-1.817	.001	<.001	3	4
BLOOD_Myeloma	ATP6V1B2 →	-1.374	-1.566	<.001	<.001	3	4
LUNG_SCLC	RPL24 →	-0.985	-1.577	.004	.001	3	4
LUNG_NSCLC_LUAD	AKT3 →	-1.791	-1.162	.004	<.001	3	4
OVARY	DCP1A →	-0.892	-2.081	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046321 vs CPT1A — LUNG_SCLC

Explore this scatter interactively →