Regulation of fatty acid oxidation

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JPT1, DDX21_S89, and NCL_S67, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid oxidation activity versus JPT1 in LSCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	JPT1 →	-0.514	-0.053	<.001	<.001	3	8
LUAD	DDX21_S89 →	-1.010	-0.038	<.001	<.001	3	8
LUAD	NCL_S67 →	-0.976	-0.045	<.001	<.001	3	8
PDAC	FLII_S856 →	-0.491	-0.042	.006	.001	3	7
LUAD	LARP4 →	-0.316	-0.027	<.001	<.001	3	7
LSCC	MYEF2_S17 →	+0.616	+0.022	.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046320 vs JPT1 — LSCC

Explore this scatter interactively →