Regulation of fatty acid oxidation

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid oxidation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBL2, ACYP1, and ZNF626, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBL2 grouped by Regulation of fatty acid oxidation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RBL2 →	-1.155	-0.499	.003	<.001	3	4
SOFT_TISSUE	ACYP1 →	-1.152	-0.392	.002	<.001	3	3
SOFT_TISSUE	ZNF626 →	+1.866	+0.398	<.001	.003	3	3
SOFT_TISSUE	SYCP2 →	+1.541	+0.340	.003	.007	3	3
BONE	SLC38A9 →	-0.814	-0.321	.003	.001	3	3
URINARY_TRACT	PAN2 →	-1.592	-0.425	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBL2 by Regulation of fatty acid oxidation activity — URINARY_TRACT

Explore this box plot interactively →