Phenol-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAD21, FBL, and HNRNPM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound biosynthetic process activity versus RAD21 in GBM (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAD21 →	-0.271	-0.063	.001	<.001	3	7
BRCA	FBL →	-0.258	-0.035	.002	<.001	3	7
GBM	HNRNPM →	-0.307	-0.092	<.001	<.001	3	7
GBM	RCOR3 →	-0.328	-0.069	<.001	<.001	3	6
GBM	SAFB →	-0.293	-0.063	<.001	<.001	3	6
LSCC	SART3 →	-0.166	-0.028	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046189 vs RAD21 — GBM

Explore this scatter interactively →