Phenol-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMS22L, CEP162, and CDKAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound biosynthetic process activity versus MMS22L in LUAD (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MMS22L →	-0.321	-0.589	.002	.002	3	4
LUAD	CEP162 →	-0.293	-0.503	.002	.006	3	3
LUAD	CDKAL1 →	-0.273	-0.490	<.001	.001	3	3
LUAD	UHRF2 →	-0.310	-0.595	.001	.001	3	3
LUAD	CEP78 →	-0.250	-0.449	.003	.004	3	3
LUAD	TEX30 →	-0.369	-0.500	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046189 vs MMS22L — LUAD

Explore this scatter interactively →