Phenol-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phenol-containing compound biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTMR1, UBE3C, and EIF2B1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTMR1 grouped by Phenol-containing compound biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTMR1 →	-0.250	-1.819	.009	.004	3	3
LARGE_INTESTINE	UBE3C →	-0.313	-1.851	.007	<.001	3	3
LUNG_SCLC	EIF2B1 →	-0.520	-1.668	.002	.001	3	3
LUNG_SCLC	STEAP1 →	+0.247	+1.875	<.001	<.001	3	3
SKIN	SLC22A18 →	-0.158	-0.541	.001	.001	3	3
LUNG_SCLC	B3GNT3 →	-0.260	-1.750	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTMR1 by Phenol-containing compound biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →