Phenol-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phenol-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGAP3, TIMP1, and TRAK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound biosynthetic process activity versus AGAP3 in BLOOD_Leukemia (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGAP3 →	+2.052	+0.850	<.001	.009	2	5
BREAST	TIMP1 →	+2.452	+1.487	.006	<.001	3	3
SKIN	TRAK2 →	+0.955	+0.501	.002	.009	3	3
SKIN	STRADA →	+0.544	+0.431	<.001	.004	3	3
OESOPHAGUS	SDCBP →	+1.197	+1.601	.006	.001	3	3
LUNG_NSCLC_LUAD	CHIC1 →	+0.901	+0.903	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046189 vs AGAP3 — BLOOD_Leukemia

Explore this scatter interactively →