Aldehyde biosynthetic process

Across TCGA patient cohorts, RNA activity of the Aldehyde biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB1I1_S68, ECM1, and IGFBP7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde biosynthetic process activity versus TGFB1I1_S68 in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TGFB1I1_S68 →	+0.809	+0.062	<.001	.002	3	6
PDAC	ECM1 →	+0.631	+0.049	.001	.001	2	7
PDAC	IGFBP7 →	+0.689	+0.045	<.001	.005	3	6
BRCA	SRPX2 →	+0.960	+0.047	<.001	<.001	3	5
BRCA	TIMP3 →	+0.827	+0.047	<.001	<.001	3	5
CCRCC	TPM1 →	+0.484	+0.043	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046184 vs TGFB1I1_S68 — CCRCC

Explore this scatter interactively →