Aldehyde biosynthetic process

Across TCGA patient cohorts, RNA activity of the Aldehyde biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAB1, FZD1, and C1S, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde biosynthetic process activity versus STAB1 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STAB1 →	+0.796	+0.431	<.001	.004	3	5
BRCA	FZD1 →	+0.668	+0.389	.004	.004	3	4
PDAC	C1S →	+0.381	+0.158	.001	.009	3	4
BRCA	PMP22 →	+0.730	+0.379	.001	.007	3	4
LUAD	IGSF21 →	+0.483	+0.293	<.001	.008	3	4
BRCA	CNRIP1 →	+0.635	+0.359	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046184 vs STAB1 — LUAD

Explore this scatter interactively →