Aldehyde biosynthetic process

Across TCGA cell cohorts, RNA activity of the Aldehyde biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TKT, TXN2, and POLR3K, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde biosynthetic process activity versus TKT in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TKT →	+1.029	+0.149	<.001	<.001	3	8
URINARY_TRACT	TXN2 →	+0.718	+0.426	<.001	<.001	3	5
URINARY_TRACT	POLR3K →	+0.840	+0.527	.003	<.001	2	6
STOMACH	CANT1 →	-1.269	-0.118	.008	.009	2	6
SKIN	PMF1 →	+0.412	+0.146	.003	<.001	3	5
BLOOD_Leukemia	PHACTR2 →	-1.057	-0.057	.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046184 vs TKT — BREAST

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