Polyol catabolic process

Across TCGA cell cohorts, RNA activity of the Polyol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TC2N, PRXL2B, and GPD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol catabolic process activity versus TC2N in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TC2N →	+3.525	+0.294	<.001	<.001	3	6
BREAST	PRXL2B →	+0.779	+0.197	<.001	<.001	3	6
CNS	GPD2 →	+1.490	+0.260	<.001	<.001	3	5
OVARY	ASS1 →	+3.027	+0.212	.005	.003	3	5
OVARY	TMC6 →	+1.733	+0.190	.004	<.001	3	5
OVARY	TMEM41A →	+0.929	+0.217	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046174 vs TC2N — URINARY_TRACT

Explore this scatter interactively →