Polyol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polyol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAG2, EMG1, and CLU_S396, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol biosynthetic process activity versus STAG2 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAG2 →	-0.324	-0.057	<.001	<.001	3	7
BRCA	EMG1 →	-0.520	-0.027	<.001	<.001	3	7
PDAC	CLU_S396 →	+1.162	+0.064	.004	.002	3	6
LSCC	MDN1 →	-0.300	-0.041	.008	<.001	3	6
BRCA	NUP155 →	-0.243	-0.028	<.001	<.001	3	6
GBM	ADNP →	-0.433	-0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046173 vs STAG2 — GBM

Explore this scatter interactively →