Polyol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polyol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A2, GPD1L, and TIRAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol biosynthetic process activity versus COL6A2 in OESOPHAGUS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COL6A2 →	-2.438	-0.170	.003	.006	3	6
BREAST	GPD1L →	+1.417	+0.280	.001	<.001	3	6
BLOOD_Lymphoma	TIRAP →	+0.921	+0.177	.001	.005	2	6
SKIN	CITED1 →	+1.687	+0.244	.005	.009	3	5
LARGE_INTESTINE	DUS3L →	+0.850	+0.258	.001	<.001	3	5
LUNG_NSCLC_LUAD	EVA1B →	-1.536	-0.230	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046173 vs COL6A2 — OESOPHAGUS

Explore this scatter interactively →