Polyol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polyol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPR, GOT1, and PCBD1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol biosynthetic process activity versus SPR in STOMACH (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPR →	+1.494	+0.263	<.001	.008	3	12
STOMACH	GOT1 →	+1.571	+0.212	.009	.003	3	12
STOMACH	PCBD1 →	+2.790	+0.241	<.001	<.001	3	11
STOMACH	APEH →	+1.812	+0.272	<.001	<.001	3	10
STOMACH	PPP2R1A →	+1.022	+0.251	.002	.001	3	10
SKIN	MTPN →	+2.093	+0.348	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046173 vs SPR — STOMACH

Explore this scatter interactively →