Alcohol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC18, RARS1, and H2AC19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alcohol biosynthetic process activity versus CCDC18 in GBM (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCDC18 →	-0.732	-0.223	<.001	<.001	3	6
LUAD	RARS1 →	-0.356	-0.123	<.001	<.001	3	5
LSCC	H2AC19 →	-0.484	-0.128	.007	.008	3	5
LUAD	MRTO4 →	-0.305	-0.104	.006	.003	3	5
GBM	CHD4 →	-0.137	-0.126	.002	.002	3	5
GBM	RPAP2 →	-0.417	-0.201	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046165 vs CCDC18 — GBM

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