Alcohol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGC, ZMYND8, and GLT8D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGC grouped by Alcohol biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PIGC →	-0.587	-0.222	.006	.002	3	5
SOFT_TISSUE	ZMYND8 →	-1.555	-1.393	.002	<.001	3	4
SOFT_TISSUE	GLT8D1 →	-0.662	-1.164	.004	.004	3	4
LARGE_INTESTINE	ZEB1 →	-1.262	-0.924	.004	.005	3	4
LARGE_INTESTINE	CTXN1 →	-1.226	-0.863	.004	.001	3	4
LARGE_INTESTINE	MAPK11 →	-1.369	-0.922	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGC by Alcohol biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →