Alcohol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF3, TMEM97, and CAMK2D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alcohol biosynthetic process activity versus RASSF3 in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RASSF3 →	+1.026	+0.246	.003	.003	3	7
SKIN	TMEM97 →	+0.869	+0.350	<.001	<.001	3	6
OESOPHAGUS	CAMK2D →	+0.805	+0.191	.007	.007	3	5
LIVER	FDPS →	+1.162	+0.373	.005	.006	3	5
LUNG_SCLC	EPHX2 →	+1.578	+0.147	.003	.006	3	5
SOFT_TISSUE	TOMM40 →	+1.062	+0.243	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046165 vs RASSF3 — SKIN

Explore this scatter interactively →