Pigment catabolic process

Across TCGA patient cohorts, RNA activity of the Pigment catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HES1, HMOX1, and C2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment catabolic process activity versus HES1 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HES1 →	-0.708	-0.183	.004	<.001	3	6
LSCC	HMOX1 →	+0.624	+0.208	<.001	<.001	3	6
CCRCC	C2 →	+0.782	+0.132	<.001	<.001	3	5
LUAD	CXXC4 →	-0.774	-0.131	.002	.001	3	5
GBM	FTLP3 →	+0.653	+0.124	<.001	<.001	3	5
GBM	ITGAL →	+0.710	+0.189	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046149 vs HES1 — GBM

Explore this scatter interactively →