Pigment catabolic process

Across TCGA cell cohorts, RNA activity of the Pigment catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTMA, NPAT, and EZR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment catabolic process activity versus PTMA in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTMA →	-0.940	-1.019	<.001	<.001	3	5
LUNG_SCLC	NPAT →	-0.644	-0.271	.001	.006	3	4
SKIN	EZR →	-1.021	-0.133	.002	.003	3	4
OESOPHAGUS	MAML3 →	+0.762	+0.243	.006	.001	3	4
BLOOD_Leukemia	BLVRA →	+3.044	+1.169	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KIAA0513 →	+0.842	+0.298	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046149 vs PTMA — BLOOD_Leukemia

Explore this scatter interactively →