Pigment biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pigment biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP6, PAFAH2, and CEP57, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP6 grouped by Pigment biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BMP6 →	+2.453	+1.512	.001	<.001	3	3
CNS	PAFAH2 →	+0.461	+0.742	.005	.006	3	3
CNS	CEP57 →	-0.421	-0.711	.003	.005	3	3
BLOOD_Lymphoma	CHCHD3 →	-0.879	-0.281	.004	.009	3	3
SKIN	RAB26 →	+0.850	+1.247	.004	<.001	3	3
LARGE_INTESTINE	DDR1 →	-1.120	-0.537	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP6 by Pigment biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →