Pigment biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pigment biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB9, GCFC2, and COMMD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment biosynthetic process activity versus ASB9 in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB9 →	+1.562	+0.791	.001	.003	3	5
CNS	GCFC2 →	-0.654	-0.255	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	COMMD4 →	-0.765	-0.294	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PFDN2 →	-0.642	-0.208	.004	.007	3	4
UPPER_AERODIGESTIVE_TRACT	CYFIP2 →	-1.050	-0.299	.005	.001	1	6
OVARY	LRPPRC →	-0.811	-0.344	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046148 vs ASB9 — BLOOD_Leukemia

Explore this scatter interactively →