Tetrahydrobiopterin metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrobiopterin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JCAD, PLSCR3, and SPR_S103, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrobiopterin metabolic process activity versus JCAD in LSCC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	JCAD →	-0.320	-0.044	<.001	.001	3	5
CCRCC	PLSCR3 →	-0.209	-0.051	.006	.005	3	5
GBM	SPR_S103 →	+0.568	+0.096	<.001	<.001	3	4
CCRCC	YARS2 →	+0.275	+0.065	.001	<.001	3	4
OV	JCAD_S680 →	-0.765	-0.046	.001	.007	3	4
LSCC	PEAK1 →	-0.226	-0.038	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046146 vs JCAD — LSCC

Explore this scatter interactively →