Tetrahydrobiopterin metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrobiopterin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA4, MAPK9, and CEP20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrobiopterin metabolic process activity versus HSPA4 in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HSPA4 →	+0.435	+0.141	<.001	<.001	3	5
CCRCC	MAPK9 →	+0.248	+0.139	.005	.001	3	5
BRCA	CEP20 →	+0.344	+0.115	<.001	.001	3	5
UCEC	MAGOH2P →	-0.694	-0.133	<.001	.001	3	4
HNSC	PPIAP13 →	-0.781	-0.173	.003	<.001	3	4
HNSC	RALBP1P1 →	-0.583	-0.155	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046146 vs HSPA4 — LUAD

Explore this scatter interactively →